TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29

W Qin, ACK Chung, XR Huang, XM Meng… - Journal of the …, 2011 - journals.lww.com
TGF-β/Smad3 signaling promotes fibrosis, but the development of therapeutic interventions
involving this pathway will require the identification and ultimate targeting of downstream
fibrosis-specific genes. In this study, using a microRNA microarray and real-time PCR, wild-
type mice had reduced expression of miR-29 along with the development of progressive
renal fibrosis in obstructive nephropathy. In contrast, Smad3 knockout mice had increased
expression of miR-29 along with the absence of renal fibrosis in the same model of …