Human herpes simplex virus keratitis: the pathogenesis revisited

L Remeijer, A Osterhaus, G Verjans - Ocular immunology and …, 2004 - Taylor & Francis
L Remeijer, A Osterhaus, G Verjans
Ocular immunology and inflammation, 2004Taylor & Francis
Infections with several members of the human herpesviruses are the cause of significant
ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary
and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent
HSV-1 infection continues to be the leading cause of corneal blindness in industrialized
nations. This review recapitulates the current insights in the role of the virus and the intra-
corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.
Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in industrialized nations. This review recapitulates the current insights in the role of the virus and the intra-corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.
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