Adenosine receptor crossroads in sickle cell disease

MT Gladwin - Nature Medicine, 2011 - nature.com
Nature Medicine, 2011nature.com
Adenosine therapy for sickle cell disease has been proposed to improve blood flow, mediate
cytoprotection and inhibit natural killer cell activity. Complicating this approach, adenosine
signaling also induces hemoglobin S polymerization, promoting'sickling', vasoocclusion,
hemolysis and organ damage (pages 79–86).
Adenosine therapy for sickle cell disease has been proposed to improve blood flow, mediate cytoprotection and inhibit natural killer cell activity. Complicating this approach, adenosine signaling also induces hemoglobin S polymerization, promoting 'sickling', vasoocclusion, hemolysis and organ damage (pages 79–86).
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