Visceral glomerular epithelial cells (GEC) are critical for normal permselectivity of the kidney.
Nephrin is a molecule that is expressed specifically in GEC in a structure called the slit
diaphragm and is required for normal morphology and permselectivity of GEC. However, the
mechanisms of action of nephrin are not understood precisely. The intracellular domain of
nephrin has six conserved tyrosine residues. It was hypothesized that these tyrosine
residues are phosphorylated by Src-family kinases and that this phosphorylation modulates …