Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
J Lucifora, S Arzberger, D Durantel, L Belloni… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: The molecular biology of hepatitis B virus (HBV) has been
extensively studied but the exact role of the hepatitis BX protein (HBx) in the context of
natural HBV infections remains unknown. METHODS: Primary human hepatocytes and
differentiated HepaRG cells allowing conditional trans complementation of HBx were
infected with wild type (HBV (wt)) or HBx deficient (HBV (x−)) HBV particles and
establishment of HBV replication was followed. RESULTS: We observed that cells …
extensively studied but the exact role of the hepatitis BX protein (HBx) in the context of
natural HBV infections remains unknown. METHODS: Primary human hepatocytes and
differentiated HepaRG cells allowing conditional trans complementation of HBx were
infected with wild type (HBV (wt)) or HBx deficient (HBV (x−)) HBV particles and
establishment of HBV replication was followed. RESULTS: We observed that cells …