[HTML][HTML] Genome regulation by polycomb and trithorax proteins
B Schuettengruber, D Chourrout, M Vervoort… - Cell, 2007 - cell.com
Cell, 2007•cell.com
Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG
proteins bind to specific regions of DNA and direct the posttranslational modification of
histones. Recent work suggests that PcG proteins regulate the nuclear organization of their
target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi
machinery.
developmental genes. To silence or activate gene expression, respectively, PcG and trxG
proteins bind to specific regions of DNA and direct the posttranslational modification of
histones. Recent work suggests that PcG proteins regulate the nuclear organization of their
target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi
machinery.
Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.
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