Fas/Fas ligand-mediated apoptosis of murine Langerhans cells
T Kawamura, M Azuma, N Kayagaki, S Shimada… - Journal of …, 2000 - Elsevier
Epidermal Langerhans cells (LC) are potent antigen-presenting cells (APC), that play a
crucial role in initiating cutaneous immune responses. The Fas/Fas ligand pathway has
been implicated as an important cellular pathway in the regulation of peripheral immunity.
The morphologic, functional and phenotypic characteristics of LC are becoming well-
characterized. However, the mechanisms involved in eliminating LC are poorly understood.
In this report, we demonstrated that murine epidermal LC constitutively express the Fas …
crucial role in initiating cutaneous immune responses. The Fas/Fas ligand pathway has
been implicated as an important cellular pathway in the regulation of peripheral immunity.
The morphologic, functional and phenotypic characteristics of LC are becoming well-
characterized. However, the mechanisms involved in eliminating LC are poorly understood.
In this report, we demonstrated that murine epidermal LC constitutively express the Fas …