[PDF][PDF] Vesicles: equal in neurotransmitter concentration but not in volume

D Sulzer, R Edwards - Neuron, 2000 - cell.com
D Sulzer, R Edwards
Neuron, 2000cell.com
Progeny from Stem Cells stem cell–derived clones poses the question of mechanism. One
possibility is that there is a clock intrinsic to stem cells that determines when daughter cells
will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal
fates and when they will impression that neural stem cells persist throughout life adopt glial
fates (see figure, panel A). But as acknowland that stem cells from the adult cortex are the
same edged by Temple and colleagues, there are a number of variations on this theme that …
Progeny from Stem Cells stem cell–derived clones poses the question of mechanism. One possibility is that there is a clock intrinsic to stem cells that determines when daughter cells will be Discussions of CNS stem cell biology often leave the specified to adopt neuronal fates and when they will impression that neural stem cells persist throughout life adopt glial fates (see figure, panel A). But as acknowland that stem cells from the adult cortex are the same edged by Temple and colleagues, there are a number of variations on this theme that would allow environmental as the stem cells that build the CNS during fetal developsignals or feedback mechanisms to also modulate the ment. In fact, the properties of CNS stem cells have process. For example, it is possible that stem cells are not yet been carefully compared throughout ontogeny; programmed to generate neurons first but that a feedhowever, by analogy to stem cells of the immune system, back signal from the neurons to the stem cells induces we would expect neural stem cells to change their propglial specification (see figure, panel B). In addition to erties over time. Fetal hematopoietic stem cells (HSC) the order of specification, differences in the proliferative have a broader developmental potential than adult HSCs behavior of restricted neuronal and glial progenitors may in that they are able to make certain classes of T cells also contribute to the generation of neurons followed that are not made by adult HSCs, even when the adult by glia. For instance, neuronal and glial specification
cell.com