The role of TNF superfamily members in T-cell function and diseases

M Croft - Nature Reviews Immunology, 2009 - nature.com
M Croft
Nature Reviews Immunology, 2009nature.com
Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are
expressed by T cells and various other immune and non-immune cell types are central to T-
cell function. In this Review, I discuss the biology of four different ligand–receptor
interactions—OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A
and death receptor 3—and their potential to be exploited for therapeutic benefit.
Manipulating these interactions can be effective for treating diseases in which T cells have …
Abstract
Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand–receptor interactions — OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 — and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating diseases in which T cells have an important role, including inflammatory conditions, autoimmunity and cancer. Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses.
nature.com