[HTML][HTML] Evolution of human and non-human primate CC chemokine receptor 5 gene and mrna: potential roles for haplotype and mrna diversity, differential haplotype …

S Mummidi, M Bamshad, SS Ahuja, E Gonzalez… - Journal of Biological …, 2000 - ASBMB
Polymorphisms in CC chemokine receptor 5 (CCR5), the major coreceptor of human
immunodeficiency virus 1 (HIV-1) and simian immunodeficiency virus (SIV), have a major
influence on HIV-1 transmission and disease progression. The effects of these
polymorphisms may, in part, account for the differential pathogenesis of HIV-1
(immunosuppression) and SIV (natural resistance) in humans and non-human primates,
respectively. Thus, understanding the genetic basis underlying species-specific responses …