Utilizing granulocyte colony—stimulating factor to enhance vascular graft endothelialization from circulating blood cells
Q Shi, V Bhattacharya, M Hong-De Wu… - Annals of vascular …, 2002 - Elsevier
Cells in the blood circulating through a vascular graft can contribute to endothelialization of
its flow surface. We hypothesized that granulocyte colony—stimulating factor (G-CSF) could
enhance this process by increasing circulating bone marrow progenitor cells. Ten dogs
received composite grafts that were shielded from any source of endothelialization other
than the circulating blood. On the seventh postoperative day and for 7 days thereafter, five
dogs were injected subcutaneously with 10 μg/kg/day of human G-CSF. The additional five …
its flow surface. We hypothesized that granulocyte colony—stimulating factor (G-CSF) could
enhance this process by increasing circulating bone marrow progenitor cells. Ten dogs
received composite grafts that were shielded from any source of endothelialization other
than the circulating blood. On the seventh postoperative day and for 7 days thereafter, five
dogs were injected subcutaneously with 10 μg/kg/day of human G-CSF. The additional five …