Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells
S Ebner, M Forstner, YH Wang, D Wolfram… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) endows human CD11c+ dendritic
cells (DCs) from peripheral blood with the capacity to induce proallergic T cells. TSLP is
present at high levels in the epidermis of atopic dermatitis where it appears to trigger
emigration of epidermal Langerhans cells (LCs); however, nothing else is known about the
influence of TSLP on LCs. OBJECTIVE: Effects of TSLP on human epidermal LCs were
investigated. METHODS: LCs were isolated by trypsinization from healthy human skin …
cells (DCs) from peripheral blood with the capacity to induce proallergic T cells. TSLP is
present at high levels in the epidermis of atopic dermatitis where it appears to trigger
emigration of epidermal Langerhans cells (LCs); however, nothing else is known about the
influence of TSLP on LCs. OBJECTIVE: Effects of TSLP on human epidermal LCs were
investigated. METHODS: LCs were isolated by trypsinization from healthy human skin …