BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by
multiple factors. Among them, house dust mite (HDM) allergens are important in the
development of AD. In airway allergy, HDM allergens activate innate immunity. However,
information regarding the activation of innate immunity by HDM allergens in the skin is
limited. OBJECTIVES: The inflammasome is a key regulator of pathogen recognition and
inflammation. We investigated whether HDM allergens activate the inflammasome in …