In human epidermis, β-defensin 2 is packaged in lamellar bodies
A Oren, T Ganz, L Liu, T Meerloo - Experimental and molecular pathology, 2003 - Elsevier
The skin presents a mechanical, as well as an immunological barrier to infection, and
displays considerable innate immune capacity. Recently, cultured human keratinocytes
were described to produce and export a microbicidal peptide human β-defensin 2 (HBD-2).
Immunogold was used to label ultrathin cryosections of stimulated, cultured human
epidermis. HBD-2 was found to be stored in the lamellar bodies (LBs) of the stimulated
keratinocytes of the spinous layer of the epidermis. HBD-2 was also found in the intercellular …
displays considerable innate immune capacity. Recently, cultured human keratinocytes
were described to produce and export a microbicidal peptide human β-defensin 2 (HBD-2).
Immunogold was used to label ultrathin cryosections of stimulated, cultured human
epidermis. HBD-2 was found to be stored in the lamellar bodies (LBs) of the stimulated
keratinocytes of the spinous layer of the epidermis. HBD-2 was also found in the intercellular …