Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2–Toll-like receptor …

AT Vu, T Baba, X Chen, TA Le, H Kinoshita… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Staphylococcus aureus heavily colonizes the lesions of patients with atopic
dermatitis (AD) and is known to trigger a worsening of AD. However, the exact mechanism
by which S aureus promotes AD is unknown. Thymic stromal lymphopoietin (TSLP), which is
highly expressed by keratinocytes in skin lesions of patients with AD and bronchial epithelial
cells in asthmatic patients, represents a critical factor linking responses at interfaces
between the body and the environment to allergic type 2 immune responses. OBJECTIVES …