[HTML][HTML] Bleomycin hydrolase is regulated biphasically in a differentiation-and cytokine-dependent manner: relevance to atopic dermatitis
Y Kamata, M Yamamoto, F Kawakami, R Tsuboi… - Journal of biological …, 2011 - ASBMB
Loss-of-function mutation in the profilaggrin gene is a major risk factor for atopic dermatitis
(AD). Previously, we showed that a neutral cysteine protease, bleomycin hydrolase (BH),
has a role in generating natural moisturizing factors, and calpain I is an upstream protease
in the filaggrin degradation pathway. Here, we investigated the transcriptional regulatory
mechanisms of BH and the relevance of BH to AD. First, we cloned the 5′-flanking region of
BH. Deletion analyses identified a critical region for BH promoter activity within− 216 bp …
(AD). Previously, we showed that a neutral cysteine protease, bleomycin hydrolase (BH),
has a role in generating natural moisturizing factors, and calpain I is an upstream protease
in the filaggrin degradation pathway. Here, we investigated the transcriptional regulatory
mechanisms of BH and the relevance of BH to AD. First, we cloned the 5′-flanking region of
BH. Deletion analyses identified a critical region for BH promoter activity within− 216 bp …