[HTML][HTML] Dissecting the bulge in hair regeneration

P Myung, M Ito - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
P Myung, M Ito
The Journal of clinical investigation, 2012Am Soc Clin Investig
The adult hair follicle houses stem cells that govern the cyclical growth and differentiation of
multiple cell types that collectively produce a pigmented hair. Recent studies have revealed
that hair follicle stem cells are heterogeneous and dynamic throughout the hair cycle.
Moreover, interactions between heterologous stem cells, including both epithelial and
melanocyte stem cells, within the hair follicle are just now being explored. This review will
describe how recent findings have expanded our understanding of the development …
The adult hair follicle houses stem cells that govern the cyclical growth and differentiation of multiple cell types that collectively produce a pigmented hair. Recent studies have revealed that hair follicle stem cells are heterogeneous and dynamic throughout the hair cycle. Moreover, interactions between heterologous stem cells, including both epithelial and melanocyte stem cells, within the hair follicle are just now being explored. This review will describe how recent findings have expanded our understanding of the development, organization, and regeneration of hair follicle stem cells. At a basic level, this review is intended to help construct a reference point to integrate the surge of studies on the molecular mechanisms that regulate these cells.
The Journal of Clinical Investigation