IL-6 and TNF-α synergistically inhibit allograft acceptance
H Shen, DR Goldstein - Journal of the American Society of …, 2009 - journals.lww.com
Previous studies suggested that activation of the innate immune system impairs the
induction of transplantation tolerance, but the responsible inflammatory mediators have not
been identified. In this study, we examined whether IL-6 and TNF-α promote resistance to
transplantation tolerance. Using a highly immunogenic murine skin allograft model, we
found that the absence of both IL-6 and TNF-α in the graft recipient synergized with co-
stimulatory blockade to induce tolerance. Furthermore, IL-6 and TNF-α acted together to …
induction of transplantation tolerance, but the responsible inflammatory mediators have not
been identified. In this study, we examined whether IL-6 and TNF-α promote resistance to
transplantation tolerance. Using a highly immunogenic murine skin allograft model, we
found that the absence of both IL-6 and TNF-α in the graft recipient synergized with co-
stimulatory blockade to induce tolerance. Furthermore, IL-6 and TNF-α acted together to …