Objectives: The purpose of this study was to investigate the association between
haptoglobin phenotypic variation and development of cardiac transplant vasculopathy.
Background The development of coronary vasculopathy determines long-term survival after
cardiac transplantation. Serum haptoglobin levels are associated with non-transplant
atherosclerosis. In addition to free hemoglobin binding, haptoglobin influences free radical
formation, prostaglandin synthesis and angiogenesis. Three phenotypes of haptoglobin …