Advances in the biology of astrocytomas

A Guha, J Mukherjee - Current opinion in neurology, 2004 - journals.lww.com
A Guha, J Mukherjee
Current opinion in neurology, 2004journals.lww.com
Astrocytomas, like other cancers, are a result of several molecular alterations, some of which
strongly correlate to their pathological grade. However, molecular heterogeneity exists
between astrocytomas of similar grades and likely between varying micro-environmental
regions of a single tumor. Characterization of the molecular signature of an astrocytoma and
linking with the appropriate 'tailored'therapie (s) is the hope of the future.
Summary
Astrocytomas, like other cancers, are a result of several molecular alterations, some of which strongly correlate to their pathological grade. However, molecular heterogeneity exists between astrocytomas of similar grades and likely between varying micro-environmental regions of a single tumor. Characterization of the molecular signature of an astrocytoma and linking with the appropriate ‘tailored’therapie (s) is the hope of the future.
Lippincott Williams & Wilkins