Going APE over ref-1
AR Evans, M Limp-Foster, MR Kelley - Mutation Research/DNA Repair, 2000 - Elsevier
The DNA base excision repair (BER) pathway is responsible for the repair of cellular
alkylation and oxidative DNA damage. A crucial and the second step in the BER pathway
involves the cleavage of baseless sites in DNA by an AP endonuclease. The major AP
endonuclease in mammalian cells is Ape1/ref-1. Ape1/ref-1 is a multifunctional protein that
is not only responsible for repair of AP sites, but also functions as a reduction-oxidation
(redox) factor maintaining transcription factors in an active reduced state. Ape1/ref-1 has …
alkylation and oxidative DNA damage. A crucial and the second step in the BER pathway
involves the cleavage of baseless sites in DNA by an AP endonuclease. The major AP
endonuclease in mammalian cells is Ape1/ref-1. Ape1/ref-1 is a multifunctional protein that
is not only responsible for repair of AP sites, but also functions as a reduction-oxidation
(redox) factor maintaining transcription factors in an active reduced state. Ape1/ref-1 has …