The elusive nature and function of mesenchymal stem cells
C Nombela-Arrieta, J Ritz, LE Silberstein - Nature reviews Molecular …, 2011 - nature.com
C Nombela-Arrieta, J Ritz, LE Silberstein
Nature reviews Molecular cell biology, 2011•nature.comMesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in
the stromal fraction of many adult tissues and have drawn intense interest from translational
and basic investigators. MSCs have been operationally defined by their ability to
differentiate into osteoblasts, adipocytes and chondrocytes after in vitro expansion.
Nevertheless, their identity in vivo, heterogeneity, anatomical localization and functional
roles in adult tissue homeostasis have remained enigmatic and are only just starting to be …
the stromal fraction of many adult tissues and have drawn intense interest from translational
and basic investigators. MSCs have been operationally defined by their ability to
differentiate into osteoblasts, adipocytes and chondrocytes after in vitro expansion.
Nevertheless, their identity in vivo, heterogeneity, anatomical localization and functional
roles in adult tissue homeostasis have remained enigmatic and are only just starting to be …
Abstract
Mesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to differentiate into osteoblasts, adipocytes and chondrocytes after in vitro expansion. Nevertheless, their identity in vivo, heterogeneity, anatomical localization and functional roles in adult tissue homeostasis have remained enigmatic and are only just starting to be uncovered.
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