Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice
To clarify the relationship between Angiotensin II AT1 and AT2 receptors, we studied AT1
receptor mRNA and binding expression in tissues from AT2 receptor gene disrupted
(AT2−/−) female mice, where AT2 receptors are not expressed in vivo, using in situ
hybridization and quantitative autoradiography. Wild type mice expressed AT1A receptor
mRNA and AT1 receptor binding in lung parenchyma, the spleen, predominantly in the red
pulp, and in liver parenchyma. In wild type mice, lung AT2 receptors were expressed in lung …
receptor mRNA and binding expression in tissues from AT2 receptor gene disrupted
(AT2−/−) female mice, where AT2 receptors are not expressed in vivo, using in situ
hybridization and quantitative autoradiography. Wild type mice expressed AT1A receptor
mRNA and AT1 receptor binding in lung parenchyma, the spleen, predominantly in the red
pulp, and in liver parenchyma. In wild type mice, lung AT2 receptors were expressed in lung …