MAPKAP kinases—MKs—two's company, three's a crowd
M Gaestel - Nature reviews Molecular cell biology, 2006 - nature.com
Nature reviews Molecular cell biology, 2006•nature.com
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-
activated protein kinases (MAPKAPKs or MKs)—MK2, MK3 and MK5—signal to diverse
cellular targets. Although there is no known common function for all three MKs, these
kinases are involved in important processes: MKs regulate gene expression at the
transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle
progression, and are implicated in inflammation and cancer.
activated protein kinases (MAPKAPKs or MKs)—MK2, MK3 and MK5—signal to diverse
cellular targets. Although there is no known common function for all three MKs, these
kinases are involved in important processes: MKs regulate gene expression at the
transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle
progression, and are implicated in inflammation and cancer.
Abstract
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) — MK2, MK3 and MK5 — signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.
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