T cell activation
JE Smith-Garvin, GA Koretzky… - Annual review of …, 2009 - annualreviews.org
This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we
begin with a brief introduction outlining the chronology of the earliest studies that
established the basic paradigm for how the engaged TCR transduces its signals. This
review continues with a description of the current state of our understanding of TCR
signaling, as well as a summary of recent findings examining other key aspects of T cell …
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we
begin with a brief introduction outlining the chronology of the earliest studies that
established the basic paradigm for how the engaged TCR transduces its signals. This
review continues with a description of the current state of our understanding of TCR
signaling, as well as a summary of recent findings examining other key aspects of T cell …
