[HTML][HTML] Contribution of the Kir3. 1 subunit to the muscarinic-gated atrial potassium channel IKACh
The muscarinic-gated atrial potassium (I KACh) channel contributes to the heart rate
decrease triggered by the parasympathetic nervous system. I KACh is a heteromultimeric
complex formed by Kir3. 1 and Kir3. 4 subunits, although Kir3. 4 homomultimers have also
been proposed to contribute to this conductance. While Kir3. 4 homomultimers evince many
properties of I KACh, the contribution of Kir3. 1 to I KACh is less well understood. Here, we
explored the significance of Kir3. 1 using knock-out mice. Kir3. 1 knock-out mice were viable …
decrease triggered by the parasympathetic nervous system. I KACh is a heteromultimeric
complex formed by Kir3. 1 and Kir3. 4 subunits, although Kir3. 4 homomultimers have also
been proposed to contribute to this conductance. While Kir3. 4 homomultimers evince many
properties of I KACh, the contribution of Kir3. 1 to I KACh is less well understood. Here, we
explored the significance of Kir3. 1 using knock-out mice. Kir3. 1 knock-out mice were viable …