Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2)
H Rauert, A Wicovsky, N Müller, D Siegmund… - Journal of Biological …, 2010 - jbc.org
Tumor necrosis factor (TNF) elicits its biological activities by stimulation of two receptors,
TNFR1 and TNFR2, both belonging to the TNF receptor superfamily. Whereas TNFR1-
mediated signal transduction has been intensively studied and is understood in detail,
especially with respect to activation of the classical NFκB pathway, cell death induction, and
MAP kinase signaling, TNFR2-associated signal transduction is poorly defined. Here, we
demonstrate in various tumor cell lines and primary T-cells that TNFR2, but not TNFR1 …
TNFR1 and TNFR2, both belonging to the TNF receptor superfamily. Whereas TNFR1-
mediated signal transduction has been intensively studied and is understood in detail,
especially with respect to activation of the classical NFκB pathway, cell death induction, and
MAP kinase signaling, TNFR2-associated signal transduction is poorly defined. Here, we
demonstrate in various tumor cell lines and primary T-cells that TNFR2, but not TNFR1 …