[HTML][HTML] Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3
Y Du, BC Böck, KA Schachter, M Chao… - Journal of Biological …, 2005 - ASBMB
Mixed lineage kinase 3 (MLK3) functions as a mitogen-activated protein kinase kinase
kinase to activate multiple mitogen-activated protein kinase pathways. Our current studies
demonstrate that lack of MLK3 blocks signaling of activated Cdc42 to c-Jun N-terminal
kinase, giving strong support for the idea that Cdc42 is a physiological activator of MLK3. We
show herein that Cdc42, in a prenylation-dependent manner, targets MLK3 from a
perinuclear region to membranes, including the plasma membrane. Cdc42-induced …
kinase to activate multiple mitogen-activated protein kinase pathways. Our current studies
demonstrate that lack of MLK3 blocks signaling of activated Cdc42 to c-Jun N-terminal
kinase, giving strong support for the idea that Cdc42 is a physiological activator of MLK3. We
show herein that Cdc42, in a prenylation-dependent manner, targets MLK3 from a
perinuclear region to membranes, including the plasma membrane. Cdc42-induced …