Transforming growth factor βs and wound healing

S O'Kane, MWJ Ferguson - The international journal of biochemistry & cell …, 1997 - Elsevier
S O'Kane, MWJ Ferguson
The international journal of biochemistry & cell biology, 1997Elsevier
The Transforming Growth Factor β superfamily (TGFβ) is one of the most complex groups of
cytokines with widespread effects on many aspects of growth and development. The TGFβ
isoforms and other family members, eg Activins and BMPs, have diverse effects in similar
physiological situations. TGFβ is involved in the wound healing process. The three
mammalian isoforms (TGFβ1, 2 and 3) and recently other family members, eg Activin, have
been localised in healing wounds. Manipulation of the ratios of TGFβ superfamily members …
The Transforming Growth Factor β superfamily (TGFβ) is one of the most complex groups of cytokines with widespread effects on many aspects of growth and development. The TGFβ isoforms and other family members, e.g. Activins and BMPs, have diverse effects in similar physiological situations. TGFβ is involved in the wound healing process. The three mammalian isoforms (TGFβ1, 2 and 3) and recently other family members, e.g. Activin, have been localised in healing wounds. Manipulation of the ratios of TGFβ superfamily members, particularly the ratio of TGFβ1 relative to TGFβ3, reduces scarring and fibrosis. Such manipulations include reducing the levels of TGFβ1/TGFβ2 using neutralising antibodies or preventing the activation of TGFβs. In chronic or impaired wounds the exogenous addition of TGFβ superfamily members accelerates aspects of the healing process. This review summarises evidence for the role of TGFβ superfamily members in wound healing and how modulation of TGFβ levels can prevent scarring and fibrosis.
Elsevier