TβRI independently activates Smad-and CD2AP-dependent pathways in podocytes

S Xavier, T Niranjan, S Krick, T Zhang… - Journal of the …, 2009 - journals.lww.com
TGF-β regulates differentiation, growth, and apoptosis of podocytes and mediates podocyte
depletion in glomerulosclerosis. TGF-β promotes proapoptotic signaling mediated by Smad3
but also activates prosurvival pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the
latter requires the CD2-associated adaptor protein (CD2AP) in podocytes. Whether the
opposing activities mediated by Smad proteins and CD2AP involve molecular cross-talk is
unknown. Here, we report that CD2AP-dependent early activation of the antiapoptotic …