IL-17 and Th17 Cells
T Korn, E Bettelli, M Oukka… - Annual review of …, 2009 - annualreviews.org
CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets
with different cytokine profiles and distinct effector functions. Until recently, T cells were
divided into Th1 or Th2 cells, depending on the cytokines they produce. A third subset of IL-
17-producing effector T helper cells, called Th17 cells, has now been discovered and
characterized. Here, we summarize the current information on the differentiation and effector
functions of the Th17 lineage. Th17 cells produce IL-17, IL-17F, and IL-22, thereby inducing …
with different cytokine profiles and distinct effector functions. Until recently, T cells were
divided into Th1 or Th2 cells, depending on the cytokines they produce. A third subset of IL-
17-producing effector T helper cells, called Th17 cells, has now been discovered and
characterized. Here, we summarize the current information on the differentiation and effector
functions of the Th17 lineage. Th17 cells produce IL-17, IL-17F, and IL-22, thereby inducing …