[HTML][HTML] Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
Y Ogura, N Inohara, A Benito, FF Chen… - Journal of Biological …, 2001 - ASBMB
Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase
recruitment domain (CARD) linked to a nucleotide-binding domain, which regulate
apoptosis and/or NF-κB activation. Nod2, a third member of the family, was identified. Nod2
is composed of two N-terminal CARDs, a nucleotide-binding domain, and multiple C-
terminal leucine-rich repeats. Although Nod1 and Apaf-1 were broadly expressed in tissues,
the expression of Nod2 was highly restricted to monocytes. Nod2 induced nuclear factor κB …
recruitment domain (CARD) linked to a nucleotide-binding domain, which regulate
apoptosis and/or NF-κB activation. Nod2, a third member of the family, was identified. Nod2
is composed of two N-terminal CARDs, a nucleotide-binding domain, and multiple C-
terminal leucine-rich repeats. Although Nod1 and Apaf-1 were broadly expressed in tissues,
the expression of Nod2 was highly restricted to monocytes. Nod2 induced nuclear factor κB …