Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
K Matsuda, AM Piliponsky, M Iikura, S Nakae… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Mouse monoclonal IgE antibodies can promote the survival of mouse bone
marrow–derived cultured mast cells and induce the cells to secrete mediators in the
absence of known specific antigen. OBJECTIVE: To determine whether human IgE, in the
absence of known specific antigen, had effects on the mediator secretion or survival of
human mast cells. METHODS: We tested whether human IgE induced human cord blood–
derived mast cells to secrete mediators or enhanced their survival on withdrawal of stem cell …
marrow–derived cultured mast cells and induce the cells to secrete mediators in the
absence of known specific antigen. OBJECTIVE: To determine whether human IgE, in the
absence of known specific antigen, had effects on the mediator secretion or survival of
human mast cells. METHODS: We tested whether human IgE induced human cord blood–
derived mast cells to secrete mediators or enhanced their survival on withdrawal of stem cell …