Phospholipase A2-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH

K Lähdesmäki, R Plihtari, P Soininen, E Hurt-Camejo… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: Hydrolysis of LDL by phospholipase A2 (PLA2) generates free fatty acids
(FFAs) and lysophospholipids (lysoPCs). Binding of the PLA2-modified LDL to
proteoglycans, and their uptake by macrophages are increased. Since the extracellular pH
is locally decreased in advanced atherosclerotic plaques, we examined the effects of acidic
pH on PLA2-induced LDL modification and its proatherogenic consequences. RESULTS:
LDL particles were avidly hydrolyzed by sPLA2-V at pH range 7.5–5.5. With decreasing pH …