pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque
M Naghavi, R John, S Naguib, MS Siadaty, R Grasu… - Atherosclerosis, 2002 - Elsevier
Background: Atherosclerotic plaques are heterogeneous with respect to inflammation,
calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in
pH and measured pH in living human carotid endarterectomized atherosclerotic plaques
(CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aortas and human umbilical
arteries (HUA). Methods and results: We measured pH of CEA of 48 patients, nine WHHL
rabbit aortas and 11 HUA specimens (as controls) using a glass type microelectrode …
calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in
pH and measured pH in living human carotid endarterectomized atherosclerotic plaques
(CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aortas and human umbilical
arteries (HUA). Methods and results: We measured pH of CEA of 48 patients, nine WHHL
rabbit aortas and 11 HUA specimens (as controls) using a glass type microelectrode …