THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to Pathology

JP Kinet - Annual review of immunology, 1999 - annualreviews.org
JP Kinet
Annual review of immunology, 1999annualreviews.org
▪ Abstract The high affinity receptor for immunoglobulin E (designated FcεRI) is the member
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific
IgEs with cellular immunologic effector functions. This review provides background
information on FcεRI function combined with more detailed summaries of recent progress in
understanding specific aspects of FcεRI biology and biochemistry. Topics covered include
the coordination and function of the large multiprotein signaling complexes that are …
Abstract
The high affinity receptor for immunoglobulin E (designated FcεRI) is the member of the antigen (Ag) receptor superfamily responsible for linking pathogen- or allergen-specific IgEs with cellular immunologic effector functions. This review provides background information on FcεRI function combined with more detailed summaries of recent progress in understanding specific aspects of FcεRI biology and biochemistry. Topics covered include the coordination and function of the large multiprotein signaling complexes that are assembled when FcεRI and other Ag receptors are engaged, new information on human receptor structures and tissue distribution, and the role of the FcRβ chain in signaling and its potential contribution to atopic phenotypes.
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