Autoxidation and MAO-mediated metabolism of dopamine as a potential cause of oxidative stress: role of ferrous and ferric ions
Á Hermida-Ameijeiras, E Méndez-Álvarez… - Neurochemistry …, 2004 - Elsevier
The autoxidation and monoamine oxidase (MAO)-mediated metabolism of dopamine (3-
hydroxytyramine; DA) cause a continuous production of hydroxyl radical (OH), which is
further enhanced by the presence of iron (ferrous iron, Fe2+ and ferric ion, Fe3+). The
accumulation of hydrogen peroxide (H2O2) in the presence of Fe2+ appears to discard the
involvement of the Fenton reaction in this process. It has been found that the presence of DA
significantly reduces the formation of thiobarbituric acid reagent substances (TBARS), which …
hydroxytyramine; DA) cause a continuous production of hydroxyl radical (OH), which is
further enhanced by the presence of iron (ferrous iron, Fe2+ and ferric ion, Fe3+). The
accumulation of hydrogen peroxide (H2O2) in the presence of Fe2+ appears to discard the
involvement of the Fenton reaction in this process. It has been found that the presence of DA
significantly reduces the formation of thiobarbituric acid reagent substances (TBARS), which …