Immune function and vaccine responses in healthy advanced elderly patients

PJ Carson, KL Nichol, J O'Brien, P Hilo… - Archives of internal …, 2000 - jamanetwork.com
Background Decline in immune function has been reported to predictably accompany
advancing age. However, to our knowledge, few studies have specifically characterized the
rapidly expanding advanced elderly population or controlled adequately for concurrent
diseases. Objective To assess whether successfully reaching an advanced age in good
health is associated with preserved immune function. Methods We prospectively compared
in vivo with in vitro variables of immune function in 29 healthy, independently living elderly …