A reassessment of the telomere hypothesis of senescence
RR Reddel - Bioessays, 1998 - Wiley Online Library
RR Reddel
Bioessays, 1998•Wiley Online LibraryAccording to the telomere hypothesis of senescence, the telomeric shortening that
accompanies the replication of normal somatic cells acts as the mitotic clock that eventually
results in their permanent exit from the cell cycle. Although evidence consistent with the
telomere hypothesis continues to accumulate, on the basis of recent findings it is suggested
that instead of a single clock mechanism there are multiple inducers of senescence.
BioEssays 20: 977–984, 1998.© 1998 John Wiley & Sons, Inc.
accompanies the replication of normal somatic cells acts as the mitotic clock that eventually
results in their permanent exit from the cell cycle. Although evidence consistent with the
telomere hypothesis continues to accumulate, on the basis of recent findings it is suggested
that instead of a single clock mechanism there are multiple inducers of senescence.
BioEssays 20: 977–984, 1998.© 1998 John Wiley & Sons, Inc.
Abstract
According to the telomere hypothesis of senescence, the telomeric shortening that accompanies the replication of normal somatic cells acts as the mitotic clock that eventually results in their permanent exit from the cell cycle. Although evidence consistent with the telomere hypothesis continues to accumulate, on the basis of recent findings it is suggested that instead of a single clock mechanism there are multiple inducers of senescence. BioEssays 20:977–984, 1998. © 1998 John Wiley & Sons, Inc.
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