Matrix management: assigning different roles for MMP-2 and MMP-9 in vascular remodeling
C Whatling, W McPheat… - … , thrombosis, and vascular …, 2004 - Am Heart Assoc
C Whatling, W McPheat, E Hurt-Camejo
Arteriosclerosis, thrombosis, and vascular biology, 2004•Am Heart AssocGeometric remodeling is an important component of vascular pathologies, including
restenosis and atherosclerosis. Although our understanding of the precise events involved
in vascular remodeling is far from complete, it is generally accepted that local breakdown of
extracellular matrix (ECM), smooth muscle cell migration, and matrix reorganization are
important components. 1 In this respect, particular attention has been directed toward the
role of matrix metalloproteinases (MMPs), enzymes capable of remodeling the ECM …
restenosis and atherosclerosis. Although our understanding of the precise events involved
in vascular remodeling is far from complete, it is generally accepted that local breakdown of
extracellular matrix (ECM), smooth muscle cell migration, and matrix reorganization are
important components. 1 In this respect, particular attention has been directed toward the
role of matrix metalloproteinases (MMPs), enzymes capable of remodeling the ECM …
Geometric remodeling is an important component of vascular pathologies, including restenosis and atherosclerosis. Although our understanding of the precise events involved in vascular remodeling is far from complete, it is generally accepted that local breakdown of extracellular matrix (ECM), smooth muscle cell migration, and matrix reorganization are important components. 1 In this respect, particular attention has been directed toward the role of matrix metalloproteinases (MMPs), enzymes capable of remodeling the ECM. However, being able to understand the specific contribution of individual members of a proteinase family that share overlapping substrates is a significant challenge.
Am Heart Assoc