The induction of tolerance by dendritic cells that have captured apoptotic cells
What makes a protein immunogenic, particularly for strong T cell–mediated immunity? To a
first approximation, this determination seems to be made by dendritic cells (DCs). Immature
DCs, as in skin (1–4), lung (5), blood (6, 7), and spleen (7, 8), take up proteins, immune
complexes, microbes, and dying cells. However, in order to use these antigens to stimulate a
T cell response, the DCs must undergo a characteristic process of terminal differentiation
called “maturation.” The known stimuli for DC maturation are numerous and include …
first approximation, this determination seems to be made by dendritic cells (DCs). Immature
DCs, as in skin (1–4), lung (5), blood (6, 7), and spleen (7, 8), take up proteins, immune
complexes, microbes, and dying cells. However, in order to use these antigens to stimulate a
T cell response, the DCs must undergo a characteristic process of terminal differentiation
called “maturation.” The known stimuli for DC maturation are numerous and include …
What makes a protein immunogenic, particularly for strong T cell–mediated immunity? To a first approximation, this determination seems to be made by dendritic cells (DCs). Immature DCs, as in skin (1–4), lung (5), blood (6, 7), and spleen (7, 8), take up proteins, immune complexes, microbes, and dying cells. However, in order to use these antigens to stimulate a T cell response, the DCs must undergo a characteristic process of terminal differentiation called “maturation.” The known stimuli for DC maturation are numerous and include inflammatory cytokines, CD40 ligand (CD40L), viral and microbial constituents such as doublestranded RNA and LPS, and certain CpG oligonucleotides.
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