Unique properties of memory B cells of different isotypes

T Kurosaki, Y Aiba, K Kometani… - Immunological …, 2010 - Wiley Online Library
T Kurosaki, Y Aiba, K Kometani, S Moriyama, Y Takahashi
Immunological reviews, 2010Wiley Online Library
Memory antibody responses are typically seen to T‐cell‐dependent antigens and are
characterized by the rapid production of high titers of high‐affinity antigen‐specific antibody.
The hallmark of T‐cell‐dependent memory B cells is their expression of a somatically
mutated, isotype‐switched B‐cell antigen receptor, features that are mainly generated in
germinal centers. Classical studies have focused on isotype‐switched memory B cells
(mainly IgG isotype) and demonstrated their unique intrinsic properties in terms of …
Summary
Memory antibody responses are typically seen to T‐cell‐dependent antigens and are characterized by the rapid production of high titers of high‐affinity antigen‐specific antibody. The hallmark of T‐cell‐dependent memory B cells is their expression of a somatically mutated, isotype‐switched B‐cell antigen receptor, features that are mainly generated in germinal centers. Classical studies have focused on isotype‐switched memory B cells (mainly IgG isotype) and demonstrated their unique intrinsic properties in terms of localization and responsiveness to antigen re‐exposure. However, recent advances in monitoring antigen‐experienced B cells have revealed the considerable heterogeneity of memory B cells, which include unswitched IgM+ and/or unmutated memory B cells. The IgM and IgG type memory B cells reside in distinct locations and appear to possess distinct origins and effector functions, together orchestrating humoral memory responses.
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