Mammalian target of rapamycin and autosomal dominant polycystic kidney disease

RP Wüthrich, AL Serra - Transplantation proceedings, 2009 - Elsevier
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive
development of innumerable cysts in both kidneys, which distort the normal kidney
architecture, leading to a loss of renal function that may necessitate renal replacement
therapy and/or kidney transplantation. In experimental animal models for dominant and
recessive forms of polycystic kidney disease, mammalian target of rapamycin (mTOR)-
inhibitors such as rapamycin effectively reduced cyst growth and loss of renal function …