The role of the mammalian target of rapamycin (mTOR) in renal disease
W Lieberthal, JS Levine - Journal of the American Society of …, 2009 - journals.lww.com
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a pivotal
role in mediating cell size and mass, proliferation, and survival. mTOR has also emerged as
an important modulator of several forms of renal disease. mTOR is activated after acute
kidney injury and contributes to renal regeneration and repair. Inhibition of mTOR with
rapamycin delays recovery of renal function after acute kidney injury. Activation of mTOR
within the kidney also occurs in animal models of diabetic nephropathy and other causes of …
role in mediating cell size and mass, proliferation, and survival. mTOR has also emerged as
an important modulator of several forms of renal disease. mTOR is activated after acute
kidney injury and contributes to renal regeneration and repair. Inhibition of mTOR with
rapamycin delays recovery of renal function after acute kidney injury. Activation of mTOR
within the kidney also occurs in animal models of diabetic nephropathy and other causes of …