Long‐term T‐cell‐mediated immunity to epstein‐barr virus in man. IV. Development of T‐cell memory in convalescent infectious mononucleosis patients

AB Rlckinson, DJ Moss, JH Pope… - International Journal of …, 1980 - Wiley Online Library
Under appropriate culture conditions, EB virus infection of lymphocytes from seropositive
donors leads to regression of transformation, and this was shown previously to be due to
activation in a secondary immune response of T lymphocytes inhibitory for the autologous
lymphoblastoid cell line. Regression can be quantified by determining the number of cells
required for its expression. To investigate the development of memory T cells with EB‐virus
specificity in the primary infection, a comparison was made of the capacity for regression of …

[CITATION][C] Long-term T-cell-mediated immunity to Epstein-Barr virus

AB Rickinson, DJ Moss, LE Wallace, M Rowe, IS Misko… - Cancer Research, 1981 - AACR
One of the central questions of EB" virus biology, crucially influencing current views of the
pathogenesis of virus-associ ated malignant disease (8, 17), concerns the nature of the
carrier state whereby the virus persists for life as an apparently nonproductive infection of
host B-lymphocytes (26). In what way does the body harbor an agent which in vitro
transforms B-cells into permanent lymphoblastoid cell lines (12, 27) with such efficiency?
The factors which serve to maintain the virus-host balance in previously infected …