[HTML][HTML] Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 …
X Fu, SY Kassim, WC Parks, JW Heinecke - Journal of Biological Chemistry, 2003 - ASBMB
Dysregulation of matrix metalloproteinase (MMP) activity is implicated in tissue destruction
under inflammatory conditions. An important mechanism controlling enzymatic activity might
involve reactive oxygen species generated by phagocytes. Myeloperoxidase, a heme
protein secreted by neutrophils, monocytes, and macrophages, uses hydrogen peroxide to
generate hypochlorous acid (HOCl). We demonstrate that HOCl inhibits the activity of human
matrilysin (MMP-7) in vitro, suggesting that it might limit proteolytic activity during …
under inflammatory conditions. An important mechanism controlling enzymatic activity might
involve reactive oxygen species generated by phagocytes. Myeloperoxidase, a heme
protein secreted by neutrophils, monocytes, and macrophages, uses hydrogen peroxide to
generate hypochlorous acid (HOCl). We demonstrate that HOCl inhibits the activity of human
matrilysin (MMP-7) in vitro, suggesting that it might limit proteolytic activity during …