Peroxisomal cholesterol synthesis in vivo: accumulation of 4-methyl intermediate sterols after aminotriazole inhibition of cholesterol synthesis
F Hashimoto, H Hayashi - Biochimica et Biophysica Acta (BBA)-Lipids and …, 1994 - Elsevier
To clarify the importance and pathway of peroxisomal cholesterol synthesis in vivo, we have
examined whether or not 4, 4-dimethyl-5α-cholest-8-en-3β-ol and 4α-methyl-5α-cholest-7-
en-3β-olare accumulated in hepatic peroxisomes of aminotriα-zole-treated rats (we have
shown that these intermediate steroids accumulate in rat liver when cholesterol synthesis is
inhibited by aminotriazole: Hashimoto, F. and Hayashi, H.(1991) Biochim. Biophys. Acta
1086, 115). Differential centrifugation and Nycodenz gradient centrifugation showed that …
examined whether or not 4, 4-dimethyl-5α-cholest-8-en-3β-ol and 4α-methyl-5α-cholest-7-
en-3β-olare accumulated in hepatic peroxisomes of aminotriα-zole-treated rats (we have
shown that these intermediate steroids accumulate in rat liver when cholesterol synthesis is
inhibited by aminotriazole: Hashimoto, F. and Hayashi, H.(1991) Biochim. Biophys. Acta
1086, 115). Differential centrifugation and Nycodenz gradient centrifugation showed that …