Background: Peanuts are a common cause of food-induced anaphylaxis and fatalities.
Previous studies have demonstrated that rush immunotherapy to crude peanut extract
reduces clinical symptoms triggered by oral peanut challenges, but the immunotherapy was
associated with an unacceptably high incidence of systemic allergic reactions. One
approach to reduce the frequency of allergic reactions would be to use a modified peanut
antigen with low allergenic properties. Objective: We sought to determine the immunologic …