Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy
N Wanich, A Nowak-Wegrzyn, HA Sampson… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Children with milk allergy who tolerate heat-denatured milk (HM) have less
severe reactions and outgrow the condition earlier than those who react to HM, which might
be related to differences in IgE-dependent effector cell function. OBJECTIVE: We sought to
apply a novel assay to test the hypothesis that HM-tolerant children have suppressed IgE-
mediated basophil responses. METHODS: Allergic, HM-tolerant, outgrown, or control
subjects were defined based on oral food challenges. Whole blood cells were stimulated in …
severe reactions and outgrow the condition earlier than those who react to HM, which might
be related to differences in IgE-dependent effector cell function. OBJECTIVE: We sought to
apply a novel assay to test the hypothesis that HM-tolerant children have suppressed IgE-
mediated basophil responses. METHODS: Allergic, HM-tolerant, outgrown, or control
subjects were defined based on oral food challenges. Whole blood cells were stimulated in …