Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1, 3-galactose
SP Commins, SM Satinover, J Hosen, J Mozena… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Carbohydrate moieties are frequently encountered in food and can elicit
IgE responses, the clinical significance of which has been unclear. Recent work, however,
has shown that IgE antibodies to galactose-α-1, 3-galactose (α-gal), a carbohydrate
commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious,
even fatal, reactions. OBJECTIVE: We sought to determine whether IgE antibodies to α-gal
are present in sera from patients who report anaphylaxis or urticaria after eating beef, pork …
IgE responses, the clinical significance of which has been unclear. Recent work, however,
has shown that IgE antibodies to galactose-α-1, 3-galactose (α-gal), a carbohydrate
commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious,
even fatal, reactions. OBJECTIVE: We sought to determine whether IgE antibodies to α-gal
are present in sera from patients who report anaphylaxis or urticaria after eating beef, pork …